Rare cell variability in gene expression
We combine high-throughput imaging with single-molecule RNA FISH to find rare cells in divergent gene expression states. We are interested in how these gene expression states drive cell behaviors and how to manipulate these states to treat disease.
De novo identification of heritable gene expression states
We recently developed a new method called MemorySeq to find gene expression states that are heritable through cell division. We believe that these expression states are associated with important phenotypes for single-cells.
Development of prognostic and diagnostic assays with single cell technologies
We are interested in developing single-molecule RNA FISH and other single-cell technologies for clinical use. We recently developed a microfluidic platform to use RNA FISH to diagnose viral infections. We plan to develop new platforms for RNA FISH and other imaging technologies on clinical samples.